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Detection
of neurodegeneration with FD NeuroSilver™ Kit I.
A: Section (40 µm)
through the dentate gyrus of the hippocampus from a rat injected with kainic
acid (10 mg/kg, s.c.), showing degenerating neurons and processes (black) in
the polymorphic layer (pl) and the molecular layer (ml), respectively. B:
Coronal section (30 µm) through the septum of a rat, killed at 10 days
following a unilateral transection of the fimbria. Note degenerating axons
(indicated by the arrow) in the ipsilateral fornix.
C: Horizontal section (40
µm) through the hippocampal dentate gyrus of a rat killed at 5 days after
the intra-entorhinal injection with aminooxyacetic acid. Note numerous
degenerating axon terminals (arrowheads) in the middle zone of the molecular
layer (ml), the terminal field of entorhinal neurons killed by the drug
injection (for details, cf. Neuroscience 82:1165, 1998).
D: Coronal section (40 µm)
throught the lateral geniculate nucleus of a rat killed at 5 days after a
unilateral visual cortex aspiration. Note dense degenerating axon terminals
in the subgeniculate nucleus (SubG). Section courtesy of Dr. E.-Y. Chen,
Rush University (D) (click to see enlarged
photo). |
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Detection
of neurodegeneration in the rat brain of a stroke model.
40 µm cryostat section was cut coronally through the striatum of a
rat used as an animal model of stroke. The section was processed for
demonstrating neuronal damage with FD NeuroSilver™ Kit I. Note the
accumulation of metallic silver grains (black) in both the striatum and the
cortex, indicating the presence of neurodegeneration.
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Detection of neurodegeneration in the rat brain of an epilepsy model. 40 µm cryostat section through the cortex of a rat used as an animal model of epilepsy. Note degenerating neurons (black) in the deep layers. | ||
