FD
NeuroSilver� Kit II
Cat. # PK301 (for 300 sections) Price: $544.00
Cat. # PK301A (for 150 sections) Price: $397.50
FD
NeuroSilver� Kit I is designed for the detection of degenerating neurons
in fixed tissue sections of the central nervous system from experimental
animals. The principle of this kit is based on the findings that some
components of the neurons undergoing degeneration, such as lysosomes, axons, and
terminals, become particularly argyrophilic. Under certain conditions, these
cellular elements bind to the silver ions with high affinity. Upon reduction, the
silver ions form metallic grains that are visible under a light or electron
microscope.
FD
NeuroSilver� Kit I has been used widely in animal studies under various
experimental conditions (cf. below for references using
this kit). This kit has proven extremely specific
and sensitive for the detection of degenerating neuronal somata, axons,
and terminals in both the brain and the spinal cord (cf. photo
samples).
It is particularly useful for the detection of small numbers of
degenerating neurons that may not be demonstrable with routine
histopathological techniques.
FD NeuroSilver� Kit I has also been proven to be very sensitive and reliable for the detection of amyloid plaques in the brain of transgenic mice (cf. photo samples ). In addition, this kit may be used for demonstrating neurodegeneration and/or amyloid plaques in tissue sections that have been processed for immunohistochemistry (cf. photo samples & also ref. 3). The procedure of FD NeuroSilver� Kit I takes approximately 1 hour.
Kit Contents: PK301A PK301
Solution A 250 ml 500 ml
Solution B 250 ml 500 ml
Solution C 250 ml x 2 500 ml x 2
Solution D 250 ml 500 ml
Solution E 1 ml 2 ml
Solution F 2 ml 3 ml
Solution G (5X) 500 ml 500 ml
Glass Specimen Retriever 2 2
User Manual 1 1
Materials Required, but Not Included:
Double distilled water
Tissue culture plates (6-well)
Histological supplies and equipment, including gelatin-coated microscope slides, glass coverslips, hair brush, staining jars, xylene or xylene substitutes and a light microscope.
User Manual
(PK301,
Version 2010-01) 
MSDS (PK301, 08152010)
References using FD Neurosilver Kit II:
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2. Valor LM, Jancic D, Lujan R, Barco A. Ultrastructural and transcriptional profiling of neuropathological misregulation of CREB function. Cell Death Differ. 17(10):1636-44, 2010.
3. Obeid M, Frank J, Medina M, Finckbone V, Bliss R, Bista B, Majmudar S, Hurst D, Strahlendorf H, Strahlendorf J. Neuroprotective effects of leptin following kainic acid-induced status epilepticus. Epilepsy Behav. PMID: 20817614, 2010.
4. Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, Dickson DW, Lewis J, Petrucelli L. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. J. Neurosci. 30(32):10851-9, 2010.
5. Kocherhans S, Madhusudan A, Doehner J, Breu KS, Nitsch RM, Fritschy JM, Knuesel I. Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice. J. Neurosci. 30(27):9228-40, 2010.
6. Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA. Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model. Hum. Mol. Genet. 19(11):2087-98, 2010.
7. Wong M, Martin LJ. Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice. Hum. Mol. Genet. 19(11):2284-302, 2010.
8. Zhou H, Huang C, Chen H, Wang D, Landel CP, Xia PY, Bowser R, Liu YJ, Xia XG. Transgenic rat model of neurodegeneration caused by mutation in the TDP gene. PLoS. Genet. 6(3):e1000887. PMID: 20361056, 2010.
9. Zhang J, Peng Q, Li Q, Jahanshad N, Hou Z, Jiang M, Masuda N, Langbehn DR, Miller MI, Mori S, Ross CA, Duan W. Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images. Neuroimage 49(3):2340-51, 2010.
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39. Choi, Dong-Young, Hunter, Randy, Liu, Mei, Cass, Wayne, Pandya, Jignesh, Sullivan, Patrick, Shin, Eun-Joo, Kim, Hyoung-Chun, Gash, Don, and Bing, Guoying. Striatal neuroinflammation promotes parkinsonism in rats. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.1970.1>, 2008.
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41. Parthasarathy KS, Cheng YC, McAllister JP 2nd, Shen Y, Li J, Deren K, Haacke EM, Auner GW. Biocompatibilities of sapphire and borosilicate glass as cortical neuroprostheses. Magn. Reson. Imaging 25(9):1333-40, 2007.
42. Liang ZQ, Li YL, Zhao XL, Han R, Wang XX, Wang Y, Chase TN, Bennett MC, Qin ZH. NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53. Brain Res. 1145:190-203, 2007.
43. Bliss RM, Hoffman T, Finckbone V, Zeitouni T, Mansouri B and Strahlendorf J. AMPA-induced excitotoxicity stimulates calpain activity and is exacerbated by tumor necrosis factor-α; (TNF-α) in the CA1 and CA3 regions of the hippocampus in an acute slice model. The FASEB Journal 21:943.2, 2007.
44. Caudle WM, Richardson JR, Wang MZ, Taylor TN, Guillot TS, McCormack AL, Colebrooke RE, Di Monte DA, Emson PC and Miller GW. Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. J. Neuroscience 27:8138-8148, 2007.
45. Kaur D, Rajagopalan S, Chinta S, Kumar J, Monte DD, Cherny RA and Andersen JK. Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Brain Research 1140:188-194, 2007.
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